ea0026p35 | Adrenal cortex | ECE2011
Bellastella G
, Visconti D
, Conzo G
, Rossi V
, Palumbo V
, De Bellis A
, Bellastella A
, Sinisi A A
Liver X receptors (LXRalfa and LXRalfa) act on the cholesterol homeostasis in several tissues, including adrenals. In particular, LXRalfa regulates the expression of several genes involved in the cholesterol efflux and storage and modulates glucocorticoid synthesis in mice. The level of the expression of LXRs in the human adrenal adenomas is unknown. We evaluated LXRalfa and LXRbeta mRNA levels in cortisol-secreting adenomas (CSA) and in the surrounding normal tissue, obtained...